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Abstract

A REVIEW OF HYDROGEL AS A DRUG CARRIER

Jakhad Suresh1, Shankar Narayan Bhunia1, Dilkush Jain1, Subhendu Mishra2, Promod Kumar Sahu 3 

1. Department of pharmaceutics, Sri Balaji College of Pharmacy, Jaipur, Rajasthan,    India

2. Department of Pharmaceutics, Radharaman College of Pharmacy, Bhopal (M.P), India
2. Department of pharmaceutics, Sapience Bioanalytical Research Laboratory, Bhopal (M.P), India

ABSTRACT

Hydrogels are three-dimensional networks formed from hydrophilic homopolymers, copolymers, or macromers (preformed macromolecular chains) crosslinked to form insoluble polymer matrices. These polymers, generally used above their glass transition temperature (Tg), are typically soft and elastic due to their thermodynamic compatibility with water and have found use in many biomedical applications. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fuids and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. Though far from extensive, the aim of this review article is to study the various method of preparation of hydrogels and there application in pharmaceutical field.

Keywords: Hydrogel, crosslinled polymer.


[Full Text Article]