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Abstract

NATURAL FLAVONOIDS OBTAINED FROM THE FLOWERS OF BUTEA MONOSPERMA INHIBITS CYCLOOXYGENASE-2 AND 5-LIPOOXYGENASE INFLAMMATION IN VARIOUS MODELS

Satyajit*1, D.Pradhan2

1. Pinnacle Bio-Medical Research Institute, Bhopal, M.P. India
2. Department of Pharmacy, Utkal University, Bhubaneshwar, Orissa, India

ABSTRACT

In this study, the flavonoid obtained from the flowers of Butea monosperma shows anti inflammatory activity by inhibiting COX-2 and 5-LOX. Also, flavonoid obtained from the flowers of Butea monosperma exhibits in-vitro on key enzymes of arachidonic acid cascade involved in the mediation of inflammation The flavonoid obtained from the flowers of Butea monosperma inhibited the COX-2 and 5- LOX enzymes with an IC50 of 56.07 μgmL-1 and 62.30 μgmL- 1 respectively. Based on the in-vitro studies data, the in-vivo anti inflammatory activity of flavonoid obtained was evaluated by using carrageenan induced paw oedema and cotton-pellet induced granuloma. The flavonoid obtained from the flowers of Butea monosperma significantly reduced the inflammation in the carrageenan induced rat paw oedema and cotton-pellet induced granuloma in rats. The flavonoid obtained from the flowers of Butea monosperma did not inhibit the gastric acid secretion. Thus, it shows that its antiulcerogenic effect which can be attributed to its action on the mucosa defence factors. The safety and efficacy profiles indicated that the flavonoid obtained from the flowers of Butea monosperma is safe for inflammatory disorders with gastric cytoprotective properties.

Keywords: Butea monosperma, Flavonoid obtained from flowers of Butea monosperma, Cyclooxygenases, Lipoxygenases, Anti inflammatory activity; Gastric acid


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