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Abstract

COGNITIVE ENHANCING ACTIVITY OF SEMECARPUS ANACARDIUM IN SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN MICE.

Nitin V. Watgure*, J. V. Vyas, A. M. Wankhade, V.V. Paithankar

Vidyabharati college of pharmacy, Amravati. Maharashtra

ABSTRACT

The present study was undertaken to investigate the effect of stem bark of Semecarpus anacardium (SA) on cognitive functions in scopolamine induced memory impairment with behavioral models Morris water maze, Object recognition test, Passive avoidance test. Memory impairment is induced by administration of scopolamine (1 mg/kg) in to the grps of mice (25-30 gm). Mice treated with extract of stem bark of Semecarpus anacardium ( 25, 50, 75 mg/kg) . Qualitative phytochemical screening of aqueous extract of SA shows a Alkaloids, tannins, flavonoids, phenolics compounds, terpenoids and steroids. Mean escape latency in Morris water maze, Discrimination index in object recognition test, were also decreased.

Keywords: Semecarpus anacardium, Memory impairment, Behavioral study, stem bark, Phytochemical study.


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