Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

COLON TARGETING MICROSPHERE: A REVIEW

Manish Kumar Chakradhari*, Anurag Sharma, Dilip Agrawal, M.P. Khinchi, Natasha Sharma, M.K. Gupta

Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan

ABSTRACT

Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like cancer,Crohn’s disease, ulcerative colitis, etc but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. Various routes of administration have been explored for the effective delivery of the drug to the target site. The oral route is considered to be most convenient for the administration of drugs to patients. But it has a serious drawback in conditions where localized delivery of the drug in the colon is required. Colon target aimed mainly because of less enzymatic activity, longer transit time so it is suitable to deliver the protien and peptide drugs. This review article discusses, in brief, anatomy and physiology of colon, factor affecting colonic absorption, polymer used in preparation of colon targeting microsphere and various techniques used in preparation of microsphere etc.

Keywords: Microsphere, Colon targeting, Colorectal Cancer, Gastro retentive Tract.


[Full Text Article]