Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

Effect of Becopa monnieri on DMBA-Induced Swiss Albino Mice Skin Tumorigenesis: a Preliminary Study

Narayan Gaidhani1*, Vishal Lokhande2, Kundlik Girhepunje3, Ranju Pal4

1Sonekar College of Pharmacy, Koradi, Nagpur. (M.H.) India.
2Maharashtra College of Pharmacy, Brahmapuri, (M.H.) India
3School of Pharmacy and Research, People’s University, Bhanpur, Bhopal (M.P.) India.
4Department of Pharmacy, Barkatullah University Bhopal (M.P.) India.

ABSTRACT

In the present study the inhibition of tumor incidences by extract of this plant has been evaluated on two-stage process of skin carcinogenesis in Swiss albino mice, induced by a single application of 7, 12-dimethyabenz(a)anthrecene (100 μg/ 100 μl acetone), and two weeks later, promoted by repeated application of croton oil (1% in acetone/thrice a week) till the end of the experiment (16 weeks). The tumor incidence,tumor yield, tumor burdon and cumulative number of papillomas were found to be higher in the control (without Becopa monnieri treatment) as compared to experimental animals (Becopa monnieri treated). The differences in the values of the results of experimental groups were statistically analyzed and found to be significant in comparison to the control group (p<0.05). The present study demonstrates the chemopreventive potential of Becopa monnieri extract on DMBA induced skin tumorigenesis in Swiss albino mice.

Keywords: Becopa monnieri, skin-carcinogenesis, chemoprevention, antioxidant enzymes, lipid peroxidation


[Full Text Article]