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Abstract

Formulation And Evaluation Of Ciprofloxacin Microsphere Using Different Natural Polymers

Suneel Kushwaha1*, Jagdish Rathi1, Subhendu S. Mishra2, Deepchand Mudiya2

1. NRI Institute of Pharmaceutical Sciences, Bhopal, M.P, India.

2. Sapience Bioanalytical Research Laboratory, Bhopal, M.P, India.

ABSTRACT

Microspheres of ciprofloxacin were formulated using natural polymer of Guargum and Xanthan gum by ionic crosslinking technique with an aim to prolong its release. Six formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters. Depending upon the drug to polymer ratio of Guar gum , the encapsulation efficiency , drug content and yield were found to range between 78.6±1.3 to 90.9±1.8%, 83.67±3.4 to 87.38±2.6% and 93.24±2.6 to 95.43±4.7%, respectively. Also the drug to polymer ratio of Xanthan gum , the encapsulation efficiency, drug content and yield were found to range between 64.80 ±0.025 to 68.20±0.059%, 83.83±1.76 to 88.92±1.90% and 92.38±0.045 to 93.46±0.038%, respectively. Microspheres were spherical, discrete and compact and size distribution was between 463 to 693 μm. In vitro studies were carried out at different pH for a period of 10 hr. In the formulation using Guar gum GG2 was 84.02 and Xanthan gum XG2 was 82.34 for better release.

Keywords: Ciprofloxacin, microsphere, Guargum, Xanthan gum, in vitro evaluation.antimutagenic.


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