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Abstract

A SYSTEMATIC REVIEW ON THE SYNTHESIS OF NICOTINIC ACID HYDRAZIDE HYDRAZONES

Aijaz Ah. Lone*, Jagruti M. Barabde

Department of Chemistry, Sant Gadge Baba Amravati University, Amravati 444602

ABSTRACT

The hydrazide-hydrazone Schiff bases attract the attention of researchers due to their broad coverage in medicinal field and pharmaceutical applications. There has been considerable interest in the development of novel compounds of Schiff bases hydrazones. A Schiff base is considered as an aldehyde with a C=N group instead of C=O group. Hydrazones possessing an azomethine proton constitute an important class of compounds for drug development. Hydrazone derivatives are obtained by coupling hydrazide compounds with aldehydes and ketones. In this paper review is focused on the overview of the literature findings covering the research on hydrazones Synthesized from Nicotinic acid hydrazides.

Keywords: Nicotinic acid hydrazide, aldehydes, ketones, Schiff basses and hydrazones.


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