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Abstract

FORMULATION AND EVALUATION OF TROPICAMIDE LOADED OCULAR IN SITU GEL

K.M Priti*, Satkar Prasad

Bhabha University, Bhopal (M.P.)

ABSTRACT

This study aimed to develop and evaluate a Pluronic F127-based ocular in-situ gel loaded with tropicamide for sustained drug release and enhanced ocular retention. Various formulations were prepared and characterized for clarity, drug content, in situ gelling capacity, pH, viscosity, and in vitro drug release profile. Among the formulations, F6 demonstrated optimal characteristics, including clear appearance, high drug content, and sustained drug release kinetics. Comparative analysis of regression coefficients indicated that drug release from F6 follows a diffusion-controlled mechanism. The developed formulation holds promise as a potential delivery system for tropicamide, offering prolonged therapeutic effect and improved patient compliance.

Keywords: Tropicamide, ocular drug delivery, in-situ gel, Pluronic F127, sustained release.


[Full Text Article]