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Abstract

FORMULATION AND CHARACTERIZATION OF BILAYER TABLETS OF ANTIHYPERTENSIVE DRUGS QUINAPRIL AND HYDROCHLOROTHIAZIDE

Sahil Siraj Makhani*, C. R. Doijad, Sachin B Dudhe

Maharashtra Institute of Pharmacy, Betala, Bramhapuri, Maharashtra

ABSTRACT

This study investigates the formulation, quality attributes, and performance characteristics of Hydrochlorothiazide and Quinapril tablets, with a focus on bilayer formulations. Pre-compression and post-compression parameters such as bulk density, tapped density, Carr’s index, Hausner’s ratio, hardness, friability, weight variation, thickness, and drug content were comprehensively analyzed. Dissolution rate studies provided insights into the release kinetics of the active pharmaceutical ingredients, highlighting formulation optimization strategies. Formulation F7, identified as the optimized control layer, exhibited superior drug release kinetics and mechanical integrity in bilayer tablets, ensuring dose accuracy and therapeutic efficacy.

Keywords: Hydrochlorothiazide, Quinapril, tablets, Pre-compression parameters, Post-compression parameters, Dissolution rate, Bilayer tablets, Formulation optimization.


[Full Text Article]