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Abstract

FORMULATION AND EVALUATION OF ANTIDIABETIC DRUG CONTAINING MICROSPHERES BY PROTEIN GELATION TECHNIQUE

Rupali P. Sable*, Sandip C. Atram, Subodh A. Urkunde, Anuja G. Gawai, Vrunda J. Rajput, Ganesh R. Padwale.

Department of pharmaceutics, Vidyabharati College of Pharmacy, Amravati – 444 602, India

ABSTRACT

This study examined and evaluated the use of protein gelation technique in the preparation of antidiabetic microspheres. The aim is to create a safe version that will increase the effectiveness of diabetes treatment and patient compliance. Microspheres were prepared by protein gelation method using biocompatible polymers and drug-voglibose. Various physicochemical properties of the formulation microspheres, such as particle size, drug loading capacity, encapsulation efficiency, in vitro drug release, and pharmacodynamic properties, were evaluated. The results of this study provide important information regarding the use of protein gelation technique-based microspheres in the delivery of anti-diabetes drugs.

Keywords: Antidiabetic drug, microspheres, protein gelation technique, sustained release, diabetes mellitus.


[Full Text Article]