Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF NOVEL GASTRORETENTIVE FLOATING FILM

Ankit G. Bhopaye*, Nishan N. Bobade, Vikrant P. Wankhade, Sandip C. Atram, Shrikant D. Pande

Department of pharmaceutics, Vidyabharati College of Pharmacy, Amravati – 444 602, India

ABSTRACT

This research delves into the innovative realm of gastroretentive floating film drug delivery systems, focusing specifically on the formulation and evaluation of Vildagliptin-loaded films for diabetes management. Through a meticulous 32 full factorial design, the study explores the influence of Hydroxypropyl Methylcellulose (HPMC) K4M and HPMC E4M concentrations on film properties and drug release kinetics. Comprehensive evaluations, including physical characterization, in vitro dissolution studies, and Fourier Transform Infrared Spectroscopy (FTIR) analysis, illuminate the performance of each formulation. Results highlight Batch FB8 as an optimized formulation, showcasing superior swelling index and extended drug release over 12 hours. This research signifies a pivotal step forward in advancing gastroretentive drug delivery technologies, promising enhanced therapeutic efficacy and patient compliance in diabetes therapy.

Keywords: Gastroretentive drug delivery system (GRDDS); Floating Film; Solvent Casting Method; Controlled Release; Diabetes; Vildagliptin; Floating Film Drug Delivery System.


[Full Text Article]