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Abstract

FORMULATION AND EVALUATION OF ANTIVIRAL DRUG LOADED SOLID LIPID NANOPARTICLES

Subodh A. Urkunde*, Sandeep C. Atram, Rupali P. Sable, Anuja G. Gawai

Department of pharmaceutics, Vidyabharati College of Pharmacy, Amravati – 444 602, India

ABSTRACT

The aim of the present study was to prepare antiviral drug loaded solid lipid nanoparticles (SLNs). Antiviral drug loaded SLNs were prepared by solvent evaporation method. The nanoparticles were further characterized for particle size, zeta potential, surface morphology, drug entrapment efficiency, and in vitro drug release behavior. The results revealed that this method is reproducible, more feasible and led to the entrapment of drug with an expected sustained release. The nanoparticle precipitated was with particle size of 167.3 nm, zeta potential of −38.2 mV, and spherical in shape. The entrapment efficiency noted was 78.10%. In vitro release was about 92.34% release in 24 h. When the regression coefficient values were compared, it was observed that ‘R2’ values of first order was maximum i.e. 0.9921 hence indicating drug release from formulation was found to follow first order release kinetics. Antiviral drug-loaded SLNs may be a good choice for the improvement of bioavailability and reduction in toxicity.

Keywords: Solid lipid nanoparticles (SLN), Acyclovir, SEM, Entrapment efficiency.


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