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Abstract

A REVIEW ON NOVEL CUBOSOMAL DRUG DELIVERY SYSTEM

Priyanka Kumari, Pranjul Shrivastava*, Khushboo Gupta, Rashmi Pandey, Sandip Prasad Tiwari

Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh India (492101)

ABSTRACT

Cubosomes are spherical or square particles with visible internal cubic lattices. The intriguing story of the discovery of the cubosome incorporates concepts from biological membranes, differential geometry, food science, and digestive processes. Cubosomes are thermodynamically stable and feature a "honey combed" structure. Cubosome production composed of lipids that are amphiphilic and are joined by a polymer. Cubosomes can be applied parenterally, orally, mucosally, transdermally, or elsewhere to treat skin, hair, and other biological tissues. Polymers can be used to target the outer circle, and cubosome formation can be adjusted to incorporate bioactive lipids or to design the pore size. Drugs that are hydrophilic, lipophilic, or amphiphilic can all be loaded into cubosomes. Either a top-down or bottom-up method can be used to prepare this. Monoolein is the primary precursor for the creation of cubosomes, while poloxamer 407 is used as a surfactant in the disperse phase at concentrations ranging from 0% to 20% w/w.

Keywords: Cubosomes, amphiphilic, encapsulated, bioreactors, biosensors.


[Full Text Article]