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Abstract

HYDROGEL INNOVATION EXPLORING CUTTING-EDGE DEVELOPMENTS

Poonam Prabhakar, Khushboo Gupta*, Pranjul Shrivastava, Sandip Prasad Tiwari

Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh India (492101)

ABSTRACT

Hydrogels are cross-linked polymers with hydrophilic groups which enable them to absorb large amounts of water. Although hydrogels have numerous capability and advantages in drug delivery including biocompatibility, low toxicity and good swelling behavior but depending on chemical moieties of the gel forming polymers and route of administration some limitations would appear in delivery of active pharmaceutical using hydrogel as delivery vehicle. In this review at first classification of the hydrogel with different approaches including chemical moieties, crosslinking agent behaviors and release controller mechanism was performed and limitations arise from each category was described and finally different approaches to overcome each of this limitation was proposed. Hydrogels, types of hydrogels, their properties, advantages of hydrogels and applications in medicine are discussed. Furthermore, hydrogels can be formulated in a variety of physical forms, including slabs, microparticles, nanoparticles, coatings, and films. As a result, hydrogels are commonly used in clinical practice and medicine for a wide range of applications, including Tissue engineering and Regenerative medicine, Diagnostics, Cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This biomaterial can hold large number of biological fluids and swell. When swell, they are soft and rubbery and resemble the living tissue exhibiting excellent biocompatibility. The prime objective of this article is to concern the classification of hydrogel on different bases, properties of hydrogel and its method of preparation and physical and chemical characteristics of these products and recent advantages of hydrogels.

Keywords: Hydrogels, polymers, biomolecules, crosslinking.


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