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Abstract

COMPREHENSIVE REVIEW ON ENHANCING RELEASE RATE OF TOPICAL LIPOSOMAL DICLOFENAC SODIUM FORMULATION

Muhammad Ibrahim Muhammad, Mustapha Abba, Muhammad Salihu Abdullahi, Sandip Prasad
Tiwari*

Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh India (492101)

ABSTRACT

A potential new treatment strategy for treating inflammatory joint diseases, such as rheumatoid arthritis and osteoarthritis, is topical liposomal diclofenac formulations. A summary of current developments, obstacles, and potential paths in the creation and use of these formulations may be found in this comprehensive abstract. The paper talks about the development of liposomal drug delivery methods and emphasizes how they may target tissues with diclofenac while encapsulating it and reducing systemic adverse effects. Personalized medicine techniques, targeted drug delivery systems, and combination therapy are some of the tactics that have been employed in recent research to improve the safety and efficacy of liposomal diclofenac formulations. The creation of customized liposomal formulations based on the unique needs of each patient is a major field of study. Researchers hope to improve treatment results and medication delivery by combining patient-specific factors, biomarkers, and pharmacogenomics data. Furthermore, specific targeting of inflammatory tissues is made possible by tailored drug delivery systems utilizing ligand-functionalized liposomes, which maximize therapeutic efficacy while reducing off-target effects. Personalized medicine through the use of cutting-edge technology, long-term observational studies, and analysis of empirical data are some of the suggested remedies and future research prospects. In conclusion, topical liposomal diclofenac formulations have a bright future ahead of them that might drastically alter the way inflammatory joint illnesses are treated. Researchers seek to provide safe, effective, and customized therapies that increase patient adherence, raise quality of life, and lessen the burden of various chronic disorders through cross-disciplinary collaboration with stakeholders.

Keywords: Topical Liposomal Diclofenac Formulations, Inflammation, Drug delivery systems


[Full Text Article]