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Abstract

A REVIEW ON EFFICACY OF ALOESIN IN THE TREATMENT OF HYPERPIGMENTATION

Nwachukwu precious, Saurabh Sharma*, Priyanka Saharan, Sandip Prasad Tiwari

Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh India (492101)

ABSTRACT

Hyperpigmentation is a common dermatological condition characterized by darkening of the skin due to increased melanin production. Aloesin, a natural compound derived from Aloe vera, has garnered significant attention for its potential therapeutic effects in treating hyperpigmentation. This review aims to comprehensively evaluate the efficacy of aloesin in the treatment of various hyperpigmentation disorders, including melasma, post-inflammatory hyperpigmentation, and solar lentigines. Aloesin exhibits its anti-hyperpigmentation properties through multiple mechanisms. Primarily, it inhibits tyrosinase, a key enzyme in melanogenesis, thereby reducing melanin synthesis. Additionally, aloesin demonstrates antioxidative properties, which further contribute to its protective effects against UVinduced skin damage and subsequent pigmentation. The review also highlights the limitations of current research, including small sample sizes and short study durations. Furthermore, the variability in aloesin concentrations and formulations across different studies complicates the direct comparison of results. Future research should focus on long-term clinical trials with standardized formulations to better assess the sustained efficacy and safety of aloesin. In conclusion, aloesin emerges as a promising agent in the treatment of hyperpigmentation, offering a natural and safer alternative to conventional therapies. This review underscores the need for further research to optimize its clinical application and establish standardized treatment protocols.

Keywords: Melanogenesis, Hyperpigmentation, Antioxidant, Tyrosinase


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