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Abstract

SWOT ANALYSIS OF NANO-CRYSTALS IN DRUG DELIVERY: REVIEW

Melewe Onyeoghani Emmanuel, Ray Tinotenda Kanhanda, Patrick Obeng, Sandip Prasad Tiwari*

Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh India (492101)

ABSTRACT

The components of poorly soluble drugs is an intractable challenging task in the area of drug layout, improvement and delivery. That is mainly complicated for molecules that present negative solubility in each organic and aqueous media. commonly, this is difficult to remedy using traditional system techniques and has resulted in lots of potential drug applicants not progressing past early stage development. Furthermore, some drug applicants are abandoned because of toxicity or have an unwanted biopharmaceutical profile. Oftentimes drug applicants do not present suitable processing traits to be produced and manufactured at scale. Nanocrystals and co-crystals, are revolutionary processes in crystal engineering which can resolve some of these barriers. Whilst these techniques are distinctly facile, in addition they require optimisation. Combining crystallography with nanoscience can yield Nano cocrystals that characterise the advantages of both fields, resulting in additive or synergistic results to drug discovery and improvement. Nano co-crystals as drug delivery systems can doubtlessly improve drug bioavailability and reduce the aspect-outcomes and tablet burden of many drug applicants that require persistent dosing as a part of treatment regimens. Similarly, Nano co-crystals are carrier-free colloidal drug delivery systems with particle sizes ranging between a hundred and one thousand nm comprising a drug molecule, a co-former and a possible drug delivery strategy for poorly soluble drugs. They're easy to prepare and feature vast applicability. In this newsletter, the strengths, weaknesses, opportunities and threats to the usage of Nano co-crystals are reviewed and a concise incursion into the salient elements of Nano co-crystals is undertaken.

Keywords: Bioavailability, Stability, Solubility, Colloidal Drug Delivery System.


[Full Text Article]