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Abstract

GOLD NANOPARTICLE FOR WOUND HEALING AND ANTIMICROBIAL APPLICATIONS

Aisha Kasim Baraza, Ali Muhammad, Rashmi Pandey*, Sandip Prasad Tiwari

Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh India (492101)

ABSTRACT

Gold nanoparticles (AuNPs) have gained significant attention in the field of wound healing and antimicrobial applications due to their unique physicochemical properties. Studied have highlighted the recent advances in utilizing AuNPs for wound healing and antimicrobial applications. AuNPs have shown potent antimicrobial activity against a wide range of bacteria. The mechanism of action involves the disruption of bacterial membranes and the generation of reactive oxygen species, leading to bacterial cell death. The use of AuNPs as antibacterial agents has shown promising results in preventing and treating wound infections. Their high surface area and unique physical properties promote cell proliferation, migration, and collagen synthesis. AuNPs also exhibit anti-inflammatory activity, reducing the production of pro-inflammatory cytokines and promoting the resolution of inflammation. As a result, wounds treated with AuNPs show accelerated healing, reduced scar formation, and improved tissue regeneration. The controlled release of bioactive molecules from AuNPs is another area of interest in wound healing applications. Loading therapeutic agents onto the surface of AuNPs enables site-specific delivery and sustained release, improving the therapeutic efficacy. Various bioactive molecules, including growth factors, antimicrobial agents, and anti-inflammatory drugs, have been successfully loaded onto AuNPs for targeted delivery to wounds. Overall, AuNPs hold great potential in wound healing and antimicrobial applications. Their unique physicochemical properties, antibacterial activity, promotion of wound healing, and ability for controlled drug release make them valuable tools in the development of advanced wound care strategies.

Keywords: Gold nanoparticles, Antimicrobials, Wound healing, Physicochemical


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