Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL INDOLE DERIVATIVES

¹Chhaya Chadhar*, ²Reshu Jain,³Shubham Patel,⁴Ravindra Balmiki, ⁵Ravindra Chourasiya,⁶ Shailendra Patil.

¹SVN Institute of pharmaceutical sciences, Swami Vivekananda University, Sagar Madhya Pradesh -470228
²SVN Institute of pharmaceutical sciences, Swami Vivekananda University, Sagar Madhya Pradesh -470228
³SVN Institute of pharmaceutical sciences, Swami Vivekananda University, Sagar Madhya Pradesh -470228
⁴SVN Institute of pharmaceutical sciences, Swami Vivekananda University, Sagar Madhya Pradesh -470228
⁵SVN Institute of pharmaceutical sciences, Swami Vivekananda University, Sagar Madhya Pradesh -470228
⁶SVN Institute of pharmaceutical sciences, Swami Vivekananda University, Sagar Madhya Pradesh- 470228

ABSTRACT

Indole derivatives have been a topic of substantial research interest and continue to be one of the most active areas of heterocyclic chemistry, because of their natural occurrence and pharmacological activities. We reported here in the synthesis of 3(1H-indol-3-yl)-1-[4-(arylidene) phenyl] prop-2-en-1-one and 2-amino N- arylidene-4-(1H-indol-3-yl)-6-phenylpyrimidin. The required indole-3-aldehyde has been prepared by Vilsmeir Haack reaction. Antimicrobial activity is determined based on their Invitro activity in purecultures. Invitro susceptibility testing done by Turbidimetric method & Agar diffusion method. The antimicrobial screening results presented on above table reveals that compounds B-4, B-5 exhibited good activity against S.aureus and E.Coli, at 50 μg/ml, but at 100 μg/ml and other have shown moderate activity against S.aureus, E.Coli. The compounds A-2, A-3 exhibited Good activity against S.aureus and E.coli, at 50 μg/ml, but at 100 μg/ml and other have shown moderate activity against S.aureus, E.Coli.

Keywords: Ciprofloxacin, Fluconazole, IR spectra, 1HNMR, TLC, Antifungal activity, Antibacterial activity, Staphylococcus aureus, E.Coli, Candila albicans.