Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

ANALYSIS OF ANTI HYPERLIPIDEMIC ACTIVITY OF FAGONIA ARABICA WHOLE PLANT EXTRACT

N Rukesh Gujare*, Monika Parmar, Satkar Prasad

RKDF School of Pharmaceutical Sciences, Bhopal (M.P.)

ABSTRACT

One of the most prevalent medical conditions is obesity, which is linked to abnormal blood lipid and lipoprotein levels is hyperlipidemia. But toxicological issues continue to be the main concern with anti hyperlipedemic medication. In this situation nature has potential to treat diseases without exhibiting any side effects. Thus, this study aims at assessing anti-hyperlipedemic activity of F. arabica. The plant material was collected subjected to extraction and qualitative, quantitative analysis was carried out. Further In vivo study was also conduceted. Results revealed that the % yield for pet ether & ethanolic extract was observed to be 5.7%& 10.5% respectively. The phytochemical test revealed the presence of flavonoid, phenol, protein, carbohydrate, saponin & tannin respectively. The total phenolic & flavonoid content was found to be 1.02& 0.56 mg/100mg respectively. Further effects of different treatments on food intake of diet-induced hyperlipidimic rats were analyzed. On the day 7th it was seen that for rats treated with EEFA 200mg/kg & 300mg/kg daily food intake was reduced to 22.47±0.15 g & 20.65±0.22 g respectively. The TC content was reduced to 203.56±6.54 mg/dL for rats treated with treated with EEFA 300mg/kg. Further the triglyceride content was also found to be reduced to 130.51±4.11 mg/dL. While in case of atorvastatin treated rats the triglyceride content was found to be 161.99±0.24 mg/dL. The HDL & LDL was estimated to be 61.99±3.33 & 116.46±6.11 respectively in EEFA 300mg/kg. The VLDL was found to be 27.10±1.04 mg/dL. The rats treated with EEFA 300mg/kg observed to have 8.51±0.12 mg/g fecal cholesterol excreted while fecal bile bile acid was seen to excrete in amount 3.94±0.10 mg/g. From results it can be concluded that F. arabica can be used as an adjuvant in current therapy for the treatment of hyperlipidemia or as a medicinal agent with antihyperlipidemic properties.

Keywords: Hyperlipedemia, Medicinal plants, Phytochemicals, F.arabica, HDL, LDL, VLDL, TG.


[Full Text Article]