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Abstract

FORMULATION AND CHARACTERIZATION OF BUCCAL TABLETS OF LANSOPRAZOLE

Kunwar Singh Mandloi*, Sunil Kumar, Ambika Prasad Arya, Muraree Lal, Avinash Krishnrao Kondalkar

Sun Institute of Pharmaceutical Education & Research (SIPER), Lahar

ABSTRACT

GERD is described as a "condition that develops when the reflux of stomach contents results in bothersome symptoms and/or complications." Buccal drug delivery has attracted a lot of interest and momentum since it provides outstanding benefits. The most often researched dosage type for buccal medication administration has been tablets. Therefore, the attempt has been made to formulate and characterize buccal lansoprazole tablets. In total nine different formulations were prepared. The result of pre-compression properties of Lansoprazole powder blend indicated that bulk density ranged from 0.342 to 0.358 gm/cm3 while the tapped density vzried from 0.451 to 0.463 gm/cm3. The Compressibility index extends from 22.84 to 25.00. The Hausner ratio varied from 1.293 to 1.333. Further the post compression parameters were analyzed by examining different parameters. The thickness among the formulations varied from 2.2±0.2 to 2.5±0.2 mm. The hardness stretched in between 4.2±0.1 kg/cm2 to 4.8±0.2 kg/cm2. The drug content among the formulation noted to be highest in F7 which is 99.95±0.14 %. The friability & weight variation ranged between 193±1 mg to 205±4 mg & 0.716±0.036 to 0.853±0.023%. The swelling index was observed to be maximum in case of F7 which is 110.25. The F7 formulation exhibited 98.85 % drug release in 12 hours. The In-vitro drug release data for optimized formulation F7 was exactly same which is 98.85%. Further mathematical models were applied and Regression analysis data was obtained. As the r² value observed to be highest which is 0.970 for Korsmeyer-Peppas the formulation F7 follows Korsmeyer-Peppas order release kinetics. Thus, lansoprazole was made into bioadhesive buccal tablets to prevent first pass metabolism and increase absorption.

Keywords: GERD, Lansoprazole, buccal medication, buccal drug delivery, bioadhesive, Mucoadhesive.


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