Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

An Experimental Study of Analgesic Activity of Selected Drugs in Comparison with Conventional NSAIDS

Sireesha Kalva*, Ramyasree Yenni

Department of Pharmacology, Sri Venkateshwara college of Pharmacy, Osmania University Madhapur.

ABSTRACT

Pain is an unpleasant sensation but a protective mechanism of our body. It is the most common medical complaint requiring a visit to a physician. The new non-steroidal anti-inflammatory drugs [NSAIDS] are commonly used. Healthy adult Swiss albino rats are used as experimental animals. The analgesic activity of the selected drugs were evaluated using eddy hot plate method. Rats weighing 200-250gm of either sex were divided into 6 groups. Oral diclofenac is used as standard and water for injection is used as control. Etoricoxib, Atorvastatin, Triphala and Aloe Vera are used as test drugs. The present study was conducted to evaluate and compare the anti-nociceptive activity of different selected drugs with conventional NSAIDS diclofenac in a hot model of acute pain using hot plate tests. In comparison with control group [vehicle] diclofenac showed significant increase in the reaction time at various time periods in the hot plate tests. In the hot plate model, the test drugs [etrocoxib, atorvastatin, Triphala and aloe Vera] showed a significant increase in the reaction time in comparison to control group. Our study concludes that various drugs selected etoricoxib, atorvastatin, triphala and aloe Vera have therapeutic potential for treating pain disorders and is non inferior to standard drug- Diclofenac.

Keywords: Analgesic activity, eddy’s hot plate, albino rats, Diclofenac sodium, Etoricoxib.


[Full Text Article]