Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

A NOVEL COST EFFECTIVE SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RITONAVIR AND LOPINAVIR FROM COMBINED TABLET DOSAGE FORM

B S Sudhi*, Anitha Thomas

College of Pharmaceutical Sciences Government Medical College Thiruvananthapuram Kerala, India

ABSTRACT

A simple, cost effective and sensitive UV spectrophotometric method has been developed for the simultaneous estimation of Lopinavir (LOPI) and Ritonavir (RITO) in combined tablet dosage form. The method was validated as per ICH guidelines. Ritonavir and lopinavir exhibited maximum absorbance at 240nm and 260nm. Ritonavir obeyed Beer’s law in the concentration range of 10-50μg/mL while Lopinavir obeyed the Beer’s law in the concentration range of 100-500μg/mL. Molar absorptivity of the drugs were determined. The method was developed by using simultaneous equation method. Assay of the tablet were carried out and percentage of Ritonavir present in tablet was found to be 102.93%. The percentage of lopinavir present in tablet was found to be 102.08%. The amount of drug present in the tablet lies within the IP limit.

Keywords: UV Spectrophotometry, Ritonavir, Lopinavir, Simultaneous Equation.


[Full Text Article]