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Abstract

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ANTIHYPERLIPIDIMIC ACTIVITY OF RAPHANUS SATIVUS LINN ON RATS

Jyoti Kumari*, Saeffi Thomas, Virendra Kumar Sharma, A. K. Singhai

School of Pharmacy, LNCT University, Bhopal (M.P.)

ABSTRACT

This study aimed to evaluate the phytochemical composition and pharmacological activity of Raphanus sativus Linn (radish) in relation to its anti-hyperlipidemic effects in rats. The phytochemical analysis of the plant extract revealed the presence of various bioactive compounds such as flavonoids, phenolic compounds, and alkaloids. In the pharmacological evaluation, hyperlipidemia was induced in rats using a high-fat diet, and the effects of Raphanus sativus extract on lipid profile parameters, including total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), were assessed. The study found that treatment with Raphanus sativus extract significantly reduced the levels of total cholesterol, triglycerides, and LDL-C, while increasing the levels of HDL-C in hyperlipidemic rats. These findings suggest that Raphanus sativus may possess potent anti-hyperlipidemic activity and could be a potential therapeutic agent for managing hyperlipidemia and related disorders.

Keywords: Raphanus sativus, hyperlipidemia, anti-hyperlipidemic activity, lipid profile, phytochemical analysis, rats.


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