Abstract

DEVELOPMENT AND CHARACTERIZATION OF POLYHERBAL ANTIMICROBIAL GEL FOR ACNE TREATMENT

Shivam Sharma*, Priyanka Namdeo, Govind Nayak, Parul Mehta

Lakshmi Narain College of Pharmacy, Bhopal (M.P.)

ABSTRACT

In this study development and characterization of polyherbal gel of leaves of Garcinia mangostana, Mesua ferrea and Peel of Punica granatum L. Acne vulgaris is collective disorder of the skin affects approximately 80% adolescents during their puberty stage. Medicinal plants are used all over the world to treat various diseases due to its variety of phytochemical constituents. Ideally, topical therapy is the first line treatment for many skin diseases. Among the various topical formulations, gels have been considered as a potential vehicle due to its non-sticky nature, stable and greater aesthetic value. The hydroalcoholic extract of Mesua ferrea had revealed the presence of alkaloids, flavonoids, glycosides and phenol. Phytochemical screening of peel extract of Punica granatum L showed the present of glycosides, flavonoids, diterpenes, phenol carbohydrate and saponins. The formulation PHG5 has good viscosity. In the above formulation of different gels the percentage of drug content was found that PHG5 has maximum percentage of drug content. Acne is the most common disorder treated by dermatologists. The present study was conducted to investigate the in vitro anti-acne activity of three selected medicinal plant extracts. Activity of Garcinia mangostana, Mesua ferrea and Punica granatum L. was further evaluated so that they can be developed into formulations and used commercially for treatment of acne.

Keywords: Garcinia mangostana, Mesua ferrea, Punica granatum, Polyherbal Antimicrobial gel, Acne treatment.