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Abstract

FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLET OF CIPROFLOXACIN HYDROCHLORIDE AND RANITIDINE HYDROCHLORIDE

Subhash Patel*, Payal Saiju, Dr. R.B. Goswami

Sagar Institute of Research Technology and Science- Pharmacy, Bhopal

ABSTRACT

The present study was aimed at developing gastro retentive bilayer drug delivery systems containing ranitidine HCl and ciprofloxacin HCl for the treatment of gastric ulcer to minimize the side effect, improve the prolongation of action, to reduce the frequency of drug administration. The formulation containing gastroretentive layer was designed using HPMC K 15, HPMC K4 and PVP K30 as floating agents, sodium bicarbonate and citric acid as gas-generating agent. Crospovidone, sodium starch glycolate and croscarmellose sodium was used as superdisintegrant for the preparation of immediate release layer. The prepared instant layer and gastroretentive layer was evaluated for their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the ranitidine from the immediate release layer was found to be 99.12% in 90minutes. The release of ciprofloxacin for the sustained release floating layer was found to be 99.74% in 12 hours. The present study revealed that ranitidine and ciprofloxacin bilayer tablets were successfully developed for the use against gastric ulcer.

Keywords: Ranitidine, Ciprofloxacin, Bilayer floating tab, Superdisintegrant, HPMC.


[Full Text Article]