Login

Journal Front Page

News & Events

  • Call for article for January 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 December, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • October 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 4 (October 2024 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

FORMULATION & EVALUATION OF ETHOSOMAL PATCH FOR DELIVERY OF METHOXSALENE

Vinod Dhote1*, Kanika Dhote1, Surendra Jain1, Deepti jain2

1Truba Institute of Pharmacy, Bhopal, India
2 SOPS RGPV, Bhopal, India

ABSTRACT

Transdermal drug delivery system minimizes the systemic absorption thereby increases the bioavailability. Methoxsalene is an antiplatlet drug generally avelable in tablet formulation. Oral delivery of Methoxsalene leads to its metabolism by cyp450 resulting in its active metabolite R-130964 and inactive metabolite. All the systems were characterized for vesicle morphology, particle size and entrapment efficiency by Scanning Electron Microscopy, Transmission Electron Microscopy, Differential light scattering and centrifugation respectively. The effect of different formulation variable on skin permeation of Methoxsalene was studied via synthetic semi permeable membrane by using diffusion cell. Methoxsalene entrapped ethosomal vesicles were prepared by hot method.

Keywords: Transdermal drug delivery, ethosomes, Methoxsalene, novel drug delivery system.


[Full Text Article]