Abstract

HERBAL TABLETS CONTAINING MOMORDICA CHARANTIA EXTRACT FOR ANTI DIABETIC TREATMENT

Pravin Mandry, Vinod Dhote*, Kanika Dhote, Surendra Jain

Truba Institute of Pharmacy, Bhopal, India

ABSTRACT

Diabetes mellitus (DM) is a group of disorders due to rise of glucose levels in blood as consequence of impairment of lipids, carbohydrates, proteins metabolism. Plant Momordica charantia Linn (family Cucurbitaceae) commonly known as bitter gourd is used as an antipyretic in stomachic ailments, as a carminative tonic; and antidiabetic agent; fruit contains momordium charantin, steroidal saponin, ascorbic acid, carbohydrates, mineral matters, alkaloids, glucosides, etc. The objective of study was to formulate and assess phytochemical potential using hydroalcoholic extract and evaluate its antidiabetic potential. Herbal tablets were prepared by direct compression methods and blend was evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. Formulations were evaluated for hardness, friability, weight variation, content uniformity, wetting time, water absorption ratio, disintegration time and invitro drug release. α- Amylase inhibition activity of herbal tablet formulation was studied. The results of the work indicate that the herbal tablet possessed considerable invitro anti diabetic activity and further these effects need to be confirmed using in vivo models for its effective utilization as therapeutic agents.

Keywords: Diabetes mellitus, Momordica charantia, ?- Amylase inhibition, Herbal tablet.