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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF OFLOXACIN AND DEXAMETHASONE IN-SITU GEL

Anshu Singh*, Dr. Anup Chakraborty Dr. Tarkeshwar P. Shukla, Dr. Sarita Karole, Dr. Kavita R. Loksh

Oriental College of Pharmacy, Bhopal, Madhya Pradesh

ABSTRACT

In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was to design, formulate and evaluate in situ gel to enhance the ocular penetration and therapeutic performance of ofloxacin and dexamethasone in ophthalmic delivery. formulation development of ofloxacin and dexamethasone ocular in situ gelling system using thermo reversible gelling polymer pluronic F127.Because of high concentration (20-25%) of this polymer required for In situ gelation causes irritation to the eye. So, to reduce this concentration an attempt was made to combine the pluronic F127 with other polymers like HPMC and carbopol. Viscosity of formulation was determined before and after gelation by using Brookfield’s viscometer in the small volume adaptor and the angular velocity was determined at 10rpm. The comparative study of viscosity was done at 10 rpm. F3, show comparatively better viscosity and good consistency gel. The In vitro drug release data of the optimized formulation was subjected to goodness of fit test by linear regression analysis according to zero order and first order kinetic equation in order to determine the mechanism of drug release. When the regression coefficient values of were compared, it was observed that ‘r’ values of Higuchi was maximum hence indicating drug release from formulations was found to follow Higuchi release kinetics.

Keywords: Ofloxacin, Dexamethasone, In-Situ gel, Formulation development, Evaluation.


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