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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DISSOLVING ORAL FILM OF LEVOSULPIRIDE

Ankit Kumar Shukla1*, Shradha Shende1, Vivek Jain1
, Prabhat Jain2

1NRI Institute of Pharmaceutical Science, Bhopal (M.P.)
2Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Fast dissolving oral film (FDOF) is used as a novel approach, as it dissolves rapidly in mouth and directly reaches to the systemic circulation. Oral film technology fulfills all the requirements of potential solid dosage form. The present study was aimed to formulate and evaluate fast dissolving oral films of Levosulpiride using Hydroxy Propyl Methyl Cellulose (HPMC), Sodium Starch Glycolate, Crospovidone, Croscarmellose Sodium, Mannitol and Citric Acid. The suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and stickiness of the film. The films are prepared by solvent casting method and characterized by UV, FTIR studies. The films were evaluated for disintegration time, folding endurance, thickness, percentage of moisture content, drug content and in-vitro dissolution studies. The F8 formulation has given 99.85% drug release within 10 minutes.

Keywords: Fast dissolving oral films, HPMC, solvent casting, plasticizer, Levosulpiride.


[Full Text Article]