Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE AND FORMULATION DEVELOPMENT OF SPARFLOXACIN FAST DISSOLVING TABLETS

Sourabh Gour*, Ashish jain, Parul Mehta, Rajesh Gour

School of Pharmacy, LNCT University, Bhopal (M.P.)

ABSTRACT

The objective of the present study was to prepare the fast disssolving tablet of sparfloxacin. The study revealed that physical mixture shows a sudden bursting effect and erratic pattern in their release mechanism therefore the solid dispersion was best alternate. In solid dispersion it was found that in 1:1 and 1:2 ratios there was also a bursting effect and at higher polymer ratio i.e. at 1:3 the drug release was truly delayed which can further have optimized to get better results. Therefore 1:3 ratios were found to be superior and were used for further evaluation purpose. Fast dissolving tablets tablets containing Sparfloxacin were prepared using direct compression method. Total six formulations were prepared using varying amount of Sodium Starch glycolate and Croscarmellose sodium. The prepared Tablets were further evaluated for Hardness, Friability, disintegration time, and uniformity of drug content, and Invitro Release Studies. Percentage assay of different formulation was determined by UV Vis Spectroscopy. The In-vitro dissolution studies showed that Sparfloxacin tablets formulation F4 showed maximum 98.12% over a period of 15 min. Overall the results of the dissolution rate studies indicated greater dissolution rate of Sparfloxacin from fast dissolving tablets.

Keywords: Sparfloxacin, fast disssolving tablet, Croscarmellose sodium, Sodium starch glycolate.