Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF LAMIVUDINE ENCAPSULATED SOLID LIPID NANOPARTICLES

Mohit Singh Thakur*, Khushi Chouksey, Dr. Kuldeep Ganju

Sagar Institute of Pharmacy and Technology (SIPTec), Bhopal

ABSTRACT

The aim of this study is to formulate the lamivudine loaded solid lipid nanoparticles in order to enhance the bioavailability and to reduce the dose frequency. The lamivudine loaded solid lipid nanoparticles were prepared by solvent injection method. The formulations were characterized for particle size, zeta potential, entrapment efficiency, drug content and in vitro release studies. Particle size was found to be 218.23nm, percentage entrapment efficiency was found to be 79.98±0.47%, Zeta potential was found to be - 42.23 mV and percentage drug content was found to be 75.65±0.85% for the optimized formulation F11. Lamivudine solid lipid nanoparticles using combination of polymers evolved as the optimized formulation and it releases more than 99.74% drug in 24 hrs. The optimized formulation F11 can be considered as a promising sustained drug delivery system of Lamivudine solid lipid nanoparticles providing nearly first order drug release over a period of 24 hrs. Results of this study indicated that solid lipid nanoparticles would be a promising therapeutic system for efficient delivery of the lamivudine and could possibility be advantageous in terms of increased bioavailability of lamivudine.

Keywords: Solid lipid nanoparticles, Lamivudine, Solvent injection technique, Nanoparticles.