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Abstract

Development and Evaluation of Curcumin Transferosomal Hydrogel: - A Promising Treatment for Psoriasis

Yogesh Kumar Baliarsingh1*, A.K. Singhai1, Nisha Thakre1, Subhendu S. Mishra2

1Lakshmi Narain College of Pharmacy, Bhopal, M.P, India

2Gayatri College of Pharmacy, Sambalpur, Odisha, India.

ABSTRACT

The aim of this work to develop curcumin transferosomal gel for the better treatment of Psoriasis through skin. The transferosome prepared by Modified Hand Shaking Method. In this method Soya-phosphatidylcholine, Span 80 and Salicylic acid were dissolved alcohol. Then solution was put in a round bottom flask. These were then dissolved by shaking. The mixture is subjected to evaporation to remove the organic solvent using temperature above the transition temperature of lipid by hand shaking. The characterization of trasferosome were further evaluated for vesicle size, drug entrapment efficiency, Shape and surface characterization by Microscopic observation. The vesicle size of all transfersomes varied between 178.89 and 245.65 nm whereas entrapment efficiency was found between 61.15 to 75.65%. the characterization of transferosomal gel were further evaluated for pH, viscosity, spreadability, drug content and invitro release study. The Viscosity of optimized formulation was found to be was in the range of 2361±0.046-2772±0.058 cps. In-vitro diffusion study of the transfersomes gel (F1-F6) was performed using modified Franz diffusion cell with dialysis membrane in phosphate buffer pH 7.4 for a period of 12 hours. In vitro release of the drug was found in the rage of 80.269-89.230.

Keywords: Curcumin, Transferosome, Soya-phosphatidylcholine, invitro release study.


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