Abstract

Formulation, Development and Evaluation of Sustained ReleaseGastroretentive Floating Tablets of Antidiabetic Drug using Natural Polymers

Akash Chandak*, Sunil Kumar Shah, Prabhakar Budholiya, C. K. Tyagi

College of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Sehore (M.P.)

ABSTRACT

The major therapeutic goals in subjects with type 2 diabetes are to optimize blood glucose control, induce weight loss, and normalize lipid disturbances and elevated blood pressure. Pioglitazone HCI is a new class of compounds to improve insulin sensitivity in type 2 diabetes. formulation and in vitro evaluation of floating tablet of Pilglitazone HCl. For this purpose, HPMC K4, HPMC K15 and Gaur Gum were incorporated in the formulation and the effect of polymer concentration & viscosity on floating behavior and drug release kinetics was evaluated. In House floating tablet optimized formulation (F7) showed the release of drug form gastroretentive formulation 99.85% after 12 hrs. and marketed formulation showed the release of 98.85% after 1.5 hrs. When the regression coefficient values of were compared, it was observed that ‘r2’ values of first order was maximum i.e. 0.932 hence indicating drug release from formulations was found to follow zero order kinetics, which was sufficient for FGR tablets Pioglitazone HCl. Anomalous transport was confirmed from these tablets which corresponds to diffusion of water and swelling (polymer arrangement) mechanism or mixed order kinetics have an essential role in drug release. This result is encouraging, because a longer gastric residence time is an important condition for higher bioavailability of the drugs included in the FGR release dosage forms. Prepared floating tablets of Pioglitazone HCl may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.

Keywords: Pioglitazone HCl, Gastro retentive, floating tablet, HPMC, Gaur Gum