Abstract

Carbon Tetra Chloride Induced Hepatoprotective Activity of Methanolic Extract of Euphorbia thymofolia Linn Using Albino Rats

Papiya Ghosh*, Vijeta Rajoriya, Alok Pal Jain

RKDF Collage of Pharmacy, NH-12, Hoshangabad Road , Bhopal (M.P.)

ABSTRACT

Methanolic extract of Euphorbia thymifolia showed the presence of Alkaloids, Carbohydrates, Glycosides, Phytosterols and Triterpenoids, Phenolic and Tannins, flavonoids and Saponins Hepatoprotective activity of MEET on CCl4- treated rats are shown in Table 2. It is well documented that CCl4 is biotransformed under the action of microsomal cytochrome P-450 of liver to reactive metabolites. These metabolites attributed to damage structural integrity of liver and raise the levels of SGPT. In the present study, SGPT level of positive control, Negative control, standard and different dose of plant extracts. Methanolic extract of the whole plant of E. thymifolia (MEET) at a dose of 100, 200 mg/kg, p.o. caused a significant inhibition in the levels SGPT towards the respective normal range is an indication of stabilization of plasma membrane as well as repair of hepatic tissue damage. The pretreatment with extract has prevented oxygen free radicals and thereby prevented the formation of peroxy radicals. This aspect of test extract also contributes to the hepatoprotectivity. From the results of the present investigation, it may be concluded that the aqueous extract of the leaves parts of Euphorbia thymifolia possess significant hepatoprotective activity against carbon tetrachloride induced hepatotoxicity.

Keywords: Euphorbia thymifolia, Hepatoprotective, CCL4, Phytochemical analysis