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Abstract

Development and Characterization of Colon Targeting Curcumin Nanoparticles

Shailja Gour*, B. K. Dubey, Brijesh Mishra

Technocrats Institute of Technology-Pharmacy, Bhopal (Madhya Pradesh)

ABSTRACT

Inflammatory Bowel Disease (IBD) cannot be controlled effortlessly and the reappearance is the most challenging issue for the physicians. There are various controlled and colon targeted drug delivery systems available for the treatment with limited success rate. Nanoparticles prepared by using the colon targeted polymers such as chitosan may improve the IBD due to their smaller size, unique physico chemical properties and targeting potential. The results of measurement of mean particle size of optimized formulation F2 nanoparticles were found 86.23 nm. When the regression coefficient values of were compared, it was observed that ‘r’ values of Pappas was maximum i.e. 0.949 hence indicating drug release from formulations was found to follow Pappas kinetics. . Eudragit-coated chitosan nanoparticles can be a promising carrier for colon-targeted delivery of Curcumin found to have high encapsulation efficiency and predetermined in vitro release profile.

Keywords: Inflammatory Bowel Disease, Curcumin, Chitosan, Eudragit-coated.


[Full Text Article]