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Abstract

PHYTOCHEMICAL ANALYSIS ANDIN VITRO SCREENING FOR ANTIOXIDANT, ANTIMICROBIAL, ANTIDIABETIC PROPERTIES OF TINOSPORA CRISPA LEAVES

Lekhram Paraste*, Sailesh Kumar Ghatuary, Gaurav Dubey

RKDF School of Pharmaceutical Science, Bhopal (M. P.)

ABSTRACT

Medicinal plants have therapeutic potential and are used worldwide to treat various diseases. Tinospora crispa (L.) Hook f & Thomson (Menispermaceae) found in the rainforests or mixed deciduous forests in Asia and Africa is used in traditional medicines to treat numerous health conditions. In this study, Tinospora crispa have been investigated for their antioxidant, antimicrobial, and antidiabetic activities. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenol and flavonoids were determined by the well-known test protocol available in the literature. The hydroalcoholic extracts of Tinospora crispa leaves exhibited significant and dose-dependent antioxidant activity including electron-donation ability. To analyze the antimicrobial activity, hydroalcoholic extracts of Tinospora crispa was tested by a well diffusion method against four selected strain and which shows significant inhibitory action against all the tested strain. In addition, the hydroalcoholic extracts of Tinospora crispa leaves exhibited the dose dependent α-amylase inhibitory activity with an IC50 value of acarbose and extract was found to 131.75 and 168.79µg/ml respectively indicating that Tinospora crispa is a promising source as a herbal medicine.

Keywords: Tinospora crispa, Phytochemical Analysis, Antioxidant, Antimicrobial, Antidiabetic Activity.


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