Abstract

STUDY OF PHYTOCONSTITUENTS AND EVALUATION OF ANTIPYRETIC ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF CARICA PAPAYA LINN AND TINOSPORA CORDIFOLIA ON BREWER’S YEAST INDUCED PYREXIA IN WISTAR RATS

Ram Pyare Saket, Dr. R. B. Goswami, Dr. Surendra Jain, Priyanka Rathore

Sagar Institute of Research and Technology-Pharmacy, Bhopal (M.P.)

ABSTRACT

The Plant were one of the principal sources of drugs since beginning the starting of human civilization. The aim of the study was to evaluate the antipyretic activity of hydroalcoholic leaf extract of Carica papaya Linn and Tinospora cordifolia using Brewer’s yeast-induced pyrexia model in Wister strain albino rats. The hydroalcoholic leaf extract at a dose of 100mg/kg & 200 mg/kg was evaluated for antipyretic activity. The extract of Carica papaya Linn and Tinospora cordifolia plant showed a significant (P < 0.05) dose-dependent of the antipyretic effect in yeast induced elevation of rectal temperature in experimental rats in comparison with the standard paracetamol. 36 no. of albino rats were weighing 150-200g rats were used. They were divided into six groups of six rats each groups. Group one serve as a control (n=6) and was given normal saline, group two serves as a standard group (n=6) was given 100mg/kg of paracetamol, while groups three-six serves as test groups were treated with 100mg/kg and 200mg/kg (n=6) of plant extract respectively. The body temperature of the rats was measured rectally over a period of 4hours. According to these data, therefore, suggest that extract of Carica papaya Linn and Tinospora cordifolia possesses the significant antipyretic activity and it mechanism would be by inhibition of release inflammatory mediators and prostaglandins.

Keywords: Carica Papaya Linn, Tinospora Cordifolia, Phytochemicals screened, Antipyretic activity, Yeast induced pyrexia