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Abstract

FORMULATION AND EVALUATION OF LIPOSOMAL GEL FOR EFFECTIVE TREATMENT OF ACNE

Singh Nishantkumar Ramkrishna1*, Hemant Kumar Dharma1, Neelesh Choubey1, C.K. Tyagi1, Prabhakar Budholiya1, Geeta parkhe2

1 College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore (M. P.).
2 Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. Liposomal formulations have been successfully used in the treatment of a number of dermatological diseases. Various synthetic as well as herbal drugs are incorporated into liposome to improve its efficacy. Clindamycin phosphate is an antibiotic useful for the treatment of a number of infections. It is of the lincosamide class. Clindamycin phosphate is a semi synthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. Topical Clindamycin phosphate reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes), an anaerobe found in sebaceous glands and follicles. Clindamycin loaded liposomes were prepared and characterized for vesicle size, surface charge and vesicle size, entrapment efficiency, pH measurements and stability. Clindamycin liposomal gels were formulated and evaluated comparatively with commercial gel with respect to measurement of viscosity, drug content, extrudability study, spreadability, in vitro drug diffusion study and stability studies. All the prepared liposomal gel showed acceptable physical properties, homogeneity, consistency, spreadability, viscosity and pH value. The best formulation F8 showed better anti-acne activity when compared with all formulation.

Keywords: Acne vulgaris, Clindamycin phosphate, Topical treatment, Liposomal.


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