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Abstract

ANTI-ARTHRITIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF DACTYLORHIZA HATAGIREA

Mrinal Aryan*1, C.K. Tyagi1, Hemant Kumar Sharma1, Prabhakar Budholiya1, Geeta Parkhe2

1College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore (M. P.)
2Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Dactylorhizahatagirea (D. Don) Soo (D.hatagirea) is a perennial orchid, native to the Himalayan region. This species is distributed in India, Pakistan, Afghanistan, Nepal, Tibet and Bhutan. In India, it is distributed in Jammu and Kashmir, Uttarakhand and Himachal Pradesh. Tubers of this species are supposed as a potent medicine in Leucorrhea in Traditional System of Medicine (TSM) rich source of mucilage and are used to make Salep as food and medicine, useful as expectorant and astringent. The present study was designed to investigate anti-arthritic activity of hydroalcoholic roots extract of D. hatagireain Freund’s complete adjuvant (FCA)-induced arthritis in rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total flavonoids were determined by the wellknown test protocol available in the literature. Quantitative analysis of flavonoids was carried out by aluminium chloride method. D.hatagirea was evaluated for anti-arthritic action by Freund’s adjuvant induced arthritis test in adult Albino rats (180-250gm). Rats were injected 0.1 ml of complete Freund’s adjuvant into the planter region of the left hind paw. Diclofenac sodium used as standard drug. Statistical analysis was performed using One way analysis of variance (ANOVA) followed by Dunnet’s test. P<0.05 was considered statistically significant. The hydroalcoholic extract of D.hatagirea in doses of 400 and 800 mg/kg showed 47.53% and 69.64% protection against increase in paw volume, respectively. D.hatagirea showed dose-dependent action in all the experimental models. The present study indicates that D.hatagirea has significant anti-arthritic properties.

Keywords: Arthritis, Dactylorhizahatagirea, Diclofenac sodium, Freund’s complete adjuvant, Paw volume.


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