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Abstract

PHYTOCHEMICAL SCREENING INVESTIGATION OF ANTI-INFLAMMATORY EFFECT OF HYDROALCOHOLIC EXTRACTS OF ZIZIPHUS XYLOPYRUS (RETZ.) WILLD

Divya Prajapati*1, C.K. Tyagi1, Hemant Kumar Sharma1, Prabhakar Budholiya1, Geeta Parkhe2

1College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore (M. P.)
2Scan Research Laboratory, Indrapuri, Bhopal (M.P.)

ABSTRACT

Ziziphusxylopyrus (Retz.) willd known as katber is used traditionally in the treatment of various diseases like Bronchial Asthma, Thirst, Diarrhoea and as Aphrodisiac, Antimicrobial, Antiinflammatory, Antinoceceptive and as Anticonvulsants. The present work showed phytochemical screening, invivo anti-inflammatory activities and sub-acute toxicity of hydroalcoholicextract of twigs of Ziziphusxylopyrus (retz.) Willd (Z. xylopyrus). The anti-inflammatory activity was evaluated by Carrageenan-Induced Rat Paw Edema method. Acute toxicity of the extract (2000 mg/kg) was examined in Swiss albino mice for 14 days. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. Quantitative analysis of phenolic and flavonoids was carried out by FolinsCiocalteau reagent method and aluminium chloride method respectively. Phytochemical analysis revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids. The total phenolics content of Z. xylopyrus extract was (2.56 mg/100mg), followed by flavonoids (1.25mg/100mg) respectively. Hydroalcoholic extract up to 2000 mg/kg did not produce any toxic effects. The hydroalcoholic extract of Z. xylopyrus (200 and 400 mg/kg) inhibited the inflammation induced by carrageenan in rats in a dose dependent manner. The hydroalcoholic extract of Z. xylopyrus possesses a strong antiinflammatory activity and may be considered an interesting source of effective anti-inflammatory compounds.

Keywords: Ziziphus xylopyrus (Retz.) willd, Sub-acute toxicity, anti-inflammatory effect, phytochemical screening.


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