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Abstract

FORMULATION AND EVALUATION OF SPHERICAL CRYSTAL AGGLOMERATES OF NISOLDIPINE

Hiral Bariya*, Hitesh Jain, Asit Sahu, D. B. Meshram

Pioneer Pharmacy Degree College, Vadodara, Gujarat, 390019, India

ABSTRACT

Utilization of herbs for medicinal purpose started in the early history of mankind several thousand years The aim of the present study was to prepare and characterize the spherical crystal agglomerates ofnisoldipine with different polymers like PEG 4000, PEG 6000, PVP and PVP K30 byusing Quassi emulsification solvent diffusion technique for enhancement of solubility, flowability, packability of nisoldipine.All the prepared agglomerates were evaluated for their flow behaviour, packability and solubility. The prepared spherical crystal agglomerates exhibited excellent physicochemical properties like solubility, flowability, packability compared with the pure nisoldipine. Agglomerates AG15 showed the better solubility and drug release in comparison of pure drug. The agglomerates AG15 was further characterized by using SEM, X-Ray diffractometry and differential scanning calorimetry. SEM studies showed that the crystal possesses a good spherical shape with smooth and regular surface.DSC thermo grams showed the changes in the melting peak of the nisoldipine in spherical crystal agglomerates suggesting the change in crystallinity of nisoldipine.The XRD revealed a characteristic decrease in the crystallinity of the nisoldipine.These results show that partial amorphization of drug leads to enhancement of drug solubility and dissolution rate.

Keywords: Spherical crystal agglomarates, Quassi emulsification solvent diffusion technique, Nisoldipine, Solubility, packability.


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