Abstract

A COMPREHENSIVE REVIEW ON: SUSTAINED RELEASE MATRIX TYPE DRUG DELIVERY SYSTEMS

Krishna Mandal*, Vandana Sethi, Shilpa Pahwa

School of Pharmacy, Lloyd Institute of management and Technology, Greater Noida (Delhi/NCR) 201306

ABSTRACT

The review of the matrix tablets seems to be most promising when developing an oral controlled release formulation. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they offer better patient compliance, maintain uniform drug levels, reduce dose and side effects, and increase safety margin for high potency drugs. Hydrophilic polymer matrix systems are widely used for designing oral controlled drug delivery dosage forms because of their flexibility to provide a desirable drug release profile, cost effectiveness, and broad regulatory acceptance. However, the use of hydrophilic matrix alone for extending drug release for highly water soluble drugs is restricted due to rapid diffusion of the dissolved drug through the hydrophilic gel network. For such drugs it becomes essential to include hydrophobic polymers in the matrix system.

Keywords: Matrix tablets, Hydrophilic polymers, sustained release formulations.