Abstract

EVALUATION OF TAZAROTENE LOADED TOPICAL LIPOSOMAL GEL FOR MANAGEMENT OF ACNE

A. Bhardwaj, M.L. Kori*

Vedica college of B. Pharmacy, R.K.D.F. University, Gandhi Nagar Bhopal (M.P.)

ABSTRACT

The aim was to design a liposomal delivery system for topical administration of tazarotene capable of providing controlled and localized release of the encapsulated drug in order to minimize adverse effects associated with its topical use. Liposomal drug delivery strategies can play a pivotal role in improving the topical delivery by enhancing their dermal localization with a concomitant reduction in their side effects. Tazarotene liposomal gels were formulated and evaluated comparatively with commercial gel with respect to antibacterial activity and in - vivo anti acne activity. The in-vitro and in-vivo effect of prepared formulation was confirmed by in-vitro antibacterial activity against Propionibacterium acnes (ATCC) and in-vivo anti acne activity in wistar rats. An attempt was made evaluate the topical liposomal tazarotene gel formulation for the treatment of acne in patients. Liposomal gel showed greater percentage of inhibition of acne infection against Propionibacterium acnes. The prepared liposomal gel formulations exhibit superior stability thereby increasing its potential application in transdermal delivery systems. The developed novel drug delivery system demonstrated anti acne activity Propionibacterium acnes. The findings of this investigation therefore underscore potential utility of commercialization of liposomal gel in the treatment of acne.

Keywords: Tazarotene, Liposome, Acne, Antibacterial, Gel, Topical