Abstract

DEVELOPMENT AND EVALUATION OF TOPICAL LIPOSOMAL GEL LOADED WITH TAZAROTENE IN COMBINATION WITH HYDROQUINONE

A. Bhardwaj, M.L. Kori*

Vedica college of B. Pharmacy, R.K.D.F. University, Gandhi Nagar Bhopal (M.P.)

ABSTRACT

The aim of the present study was to statistically optimize the vesicular formulations (Liposomes) for enhanced skin delivery of a model drug tazarotene in combination with gel contains hydroquinone. Regular 23 factorial designs were employed for screening of significant formulation and process variables involved in the development of liposome. The optimization batches (TL1 toTL8) were prepared by lipid film hydration method with different concentration of lecithin and cholestrol with different varying stirring speed (100 and 200 rpm) All the prepared formulation were characterized for vesicle morphology, particle size and entrapment efficiency by transmission electron microscopy (TEM). The optimized batch of tazarotene liposome TL6 was further incorporated into gel containing hydroquinone. Three different formulation (LF1, LF2, LF3) were prepared using different composition of carbopol (0.5, 1.0 and 2%) The optimized batch of tazarotene and hydroquinone incorporated gel (1%) was characterized for pH, spreadability, viscosity (cps) and in vitro drug release. The percentage drug entrapment efficiency found higher in formulation TL6, Vesicular size and drug entrapment efficiency of the optimized liposomes were found to be 180.4 nm and 69.10% respectively. In-vitro diffusion study demonstrated that the drug diffused from liposomal gel and conventional marketed gel was found to be 98.12% and 98.58% respectively. It can be concluded from the experimental results that the liposomal gel containing tazarotene in combination with hydroquinone has potential application in topical delivery.

Keywords: Tazarotene, Hydroquinone, Liposome, Gel, Topical Drug Delivery.