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Abstract

FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE FLOATING GASTRO RETENTIVE TABLET OF NIFEDIPINE USING NATURAL POLYMER

Nilesh Jain1, Prabhat Jain*2, Dharmendra Sahu1, Geeta Parkhe2, Surendra K. Jain1

1Sagar Institute of research & technology, Bhopal (M.P.)
2 Scan Research laboratories, Bhopal (M.P.)

ABSTRACT

Aim of the present study was Formulation and optimization of sustained release floating tablet of Nifedipine using natural polymer. Nifedipine is having low oral bioavailability and low half-life of about 2 to 4 hrs hence there is a need to formulate Sustained drug delivery for nifedipine for oral delivery. Nifedipine, a calcium channel blocker antihypertensive drug, is a poorly water soluble drug and belongs to BCS class II. The objective of the research work was to formulate and optimize sustained release matrix tablet using fenugreek a natural polymer, different grade of hydroxy propyl methyl cellulose (HPMC) for optimum delivery of Nifedipine.

Keywords: Nifedipine, Natural Polymer, HPMC, Sustained release


[Full Text Article]