Login

Journal Front Page

News & Events

  • April 2024 Issue delayed
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, Volume 13, Issue 2 (April 2024) Issue) schedule published on 15 April 2024 is delay due to some technical problem. It will published on 22 April 2024. Sorry for inconvenience. For other details You can vist the website http://www.ajper.com
  • Call for article for April 2024 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 March, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • January 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 1 (January 2024) Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

Formulation and Evaluation of Directly Compressible Agglomerates of Telmisartan

Ripu Daman Verma*, Jitendra Banweer, Praveen Tahilani, Gaurav Goyanar

Sagar Institute of Research Technology & Science- Pharmacy (SIRTS-P), Bhopal (M.P.)

ABSTRACT

The present work is aimed to formulate spherical agglomerates and enhance the micromeritic properties, solubility and dissolution rate of Telmisartan, a poorly water soluble anti-hypertensive drug. The poor water solubility and poor micromeritic properties of telmisartan lead to low dissolution rate and poor flow during tableting. Telmisartan spherical agglomerates were prepared by spherical agglomeration techniques using a quasi emulsion solvent diffusion method consisting of chloroform and water as good solvent and bad solvent respectively. PVP K30 and PEG 6000 in different concentration were used as hydrophilic polymers in agglomeration process. The effects of drug to excipient ratio, stirring time, temperature and stirring speed on the physical characteristics of agglomerates were investigated. The agglomerates were characterized to various physicochemical evaluations such as practical yield, drug content, particle size, IR spectroscopy, scanning electron microscopy, micromeritic properties, solubility and dissolution studies.Tablets were prepared using spherical agglomerates by direct compression and evaluated for tablet properties. Dissolution profiles of the directly compressed tablets of spherical agglomerates were compared with conventional tablets.

Keywords: Telmisartan, Spherical agglomeration, Micromeritic properties, solubility and dissolution rate.


[Full Text Article]