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Abstract

DEVELOPMENT & CHARACTERIZATION OF NISOLDIPINE LOADED MICROSPHERES

Vinod Dhote1*, KanikaDhote2, Dinesh Kumar Mishra3, Subhendu Mishra2

1Truba Institute of pharmacy, Bhopal (M.P)

2Ravishankar College of Pharmacy, Bhopal (M.P)

3College of Pharmacy, IPS Academy Indore-452012 (M.P)

ABSTRACT

The aim of the present research is to develop multiple unit dosage form as microspheres of a drug meant for management of hypertension (high blood pressure) using Nisoldipine. In the present study microspheres containing nisoldipine were prepared by Solvent evaporation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and based on these preliminary studies, different batches of microspheres were prepared by altering the drug: polymer ratio and cross-linking with calcium chloride. The size of microspheres was in range of 130-140μm. They were spherical in shape as evidenced by photomicrographs and scanning electron microscopy. The percent drug entrapment was in the range of 86-88 % and they could sustain drug release over a period of 8 hrs.

Keywords: Microspheres, Solvent evaporation method, optical microscopy, in-vitro release


[Full Text Article]