Login

Journal Front Page

News & Events

  • Call for article for July 2025 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 June, 2025 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • April 2025 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 14, Issue 2 (April 2025 Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

FORMULATION AND EVALUATION OF SODIUM ALGINATE AND HPMC MICROBEADS AS A CARRIER FOR THE CONTROLLED RELEASE OF CLONIDINE

Piyush Paliwal*, Jitendra Banweer, N.P.S. Sengar, P.D. Mehta

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal (M.P.) 462041

ABSTRACT

Clonidine Hydrochloride a centrally acting sympatholytic and Imidazoline-derivative hypotensive agent; selective α2-adrenergic agonist. It stimulates alpha2-adrenergic receptors in the brainstem to decrease sympathetic nervous system outflow. It is also administered epidurally to treat pain. The objective of the work was to design multiple unit dosage form as microbeads of a drug meant for management of anxiety and hypertensive disorder. Microbeads offers numerous advantages for releasing one of the drugs or part of the same drug immediately while remaining drug or parts of the same can be sustained release. Microbeads of Clonidine Hydrochloride obtained utilizing orifice ionic gelation technique using HPMC and sodium aliginate as a polymer with various ratios. Prepared beads were evaluated for drug entrapment, drug content, in-vitro release, release kinetic and stability study. particle size of optimized beads was determined by SEM.

Keywords: Clonidine, microbeads, HPMC, sodium alginate, ionic gelation technique.


[Full Text Article]