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Abstract

Floating gastro retentive systems: a potential emergence to oral drug delivery systemFloating gastro retentive systems: a potential emergence to oral drug delivery system

Vinod Dhote1*, KanikaDhote2, Mishra Dinesh Kumar3

1Truba Institute of Pharmacy, Bhopal (M.P)
2Ravishankar College of Pharmacy, Bhopal(M.P)
3College of Pharmacy, IPS Academy Indore-452012 (M.P)

ABSTRACT

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

Keywords: FDDS, HBS, floating gastroretentive drug delivery system.


[Full Text Article]